does cigarette smoking have a protective effect against parkinson's disease?

ôbjective: previous studies reported that individuals with parkinson’s disease are less likely to have smoking history and it seems that nicotine has a neuroprotective effect. the authors have conducted a case-control retrospective study to determine if there is an association between cigarette smoking and parkinson’s disease. methods: ïn a matched case-control study, 92 individuals with parkinson’s disease (71 men, 21 women mean age: 67.3±11 year) were compared to 184 people without such a diagnosis. (144 men, 40 women mean age: 65.7±12.3 year). results: nineteen patients in the group with a diagnosis of parkinson’s disease (20.6%) were smoker. ïn the control group, however, there were 103 smokers. âlso, we found a dose-response correlation between amount of smoking and higher risk of having parkinson’s disease. çonclusion: çonsistent with the results of previous studies, we found that individuals with parkinson’s disease are significantly less likely to have smoked regularly than those without parkinson’s disease.